ATCAD 2D is a native 64-bit 2D CAD for Windows. It opens, edits and saves DXF files from R12 to 2018 and offers a familiar command line, parametric constraints, dynamic blocks and full dimensioning. Perpetual license, no subscription.
This 3D graphics editing tool can be easily used for molecule creation. Falco Molecule is a 3D graphics editor for molecule creating. You can use this OpenGL editor in order to generate chemical molecules