Define a Key Combination as Hot Key
Register Hot Key(s) & Launch Programs / Open File with with Hot Key
The Program sits in System Tray
Remove Hot Keys whenever not required
A Free Windows Utility by RTMenu.com

• Mute on Lock 1.0
  Mute on Lock is a tiny resident utility that sits in the system tray and monitors your session: when you are locking your Windows workstation, it mutes the sound of your speakers....

• Power Monitor Off 3.0
  Power Off Monitor Whenever Required & Save Power

• CDDoor 3.
  CDDoor - small utility permitting to open and to close CD-ROM by pressing of the hot key or from the menu. Also shows presence of the disk in the drive by the tray's icon.

• ShowDT 3.06.2
  ShowDT 2001 is a simple utility that allows you to uncover and restore your desktop with the single click of an icon in the system tray

• LaunchPad Event Scheduler 3.23
  LaunchPad is a task scheduler for Windows. You can run those onerous, oft-put-off tasks after normal operating hours, like disk optimization, tape backups, daily reports, etc. In addition, you can run DOS commands, run/quit any program, communicate with programs using DDE commands and scripts, display a message, send keystrokes to programs,...

• Ez-ScreenShot 2.08
  EZ-ScreenShot - Easy-to-Use Screen Capture Utility Ez-ScreenShot is a small and easy to use utility that sits in the Windows system tray and enables you to capture the screen (or a any window), shrink it, edit it, and send it as a compressed (jpeg) file via Email or Messengers